When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.

When Squish, a meek amoeba who loves the comic book exploits of his favorite hero, "Super Amoeba," starts feeling sick, he worries he has caught a deadly illness.

Por burlarse del nombre del profesor Pipicaca, Jorge y Beto están a punto de hacer que su nuevo maestro de ciencia enloquecido de rabia se apodere del planeta entero. Pero Capitán Calzoncillos viene al rescate. When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous...

When Nate, Teddy, and Fiona attend the Kanigher Falls Comic Convention, they find themselves up against a group of supervillains attempting to steal a valuable comic book.