Ed, Alphonse and their mechanic Winry go south in search of Izumi Curtis, the master alchemist who tauight the brothers how to use alchemy, but an encounter with a pickpocket turns them down a different path.

Alchemy: the mystical power to alter the natural world, somewhere between magic art, and science. When two brothers, Edward and Alphonse Elric, dabbled in these powers to grant their dearest wish, one of them lost an arm and leg...and the other became nothing but a soul locked into a body of living iron. Now they are agents of the government, slaves of the military -alchemical complex, using their unique powers to obey their orders...even to kill....

Ed and Alphonse try to use their newfound skills to resurrect their dead mother, but by doing so they encounter something more terrifying than death.

After Edward Elric and his brother Alphonse attempt to raise their mother from the dead, Edward is left without and arm and leg and Alphonse's soul has been attached to a suit of armor and they must roam the earth looking for a way to restore their bodies.

While dabbling in alchemy, Edward Elric lost an arm and a leg and his brother Alphonse became a bodiless soul trapped in a suit of armor. Now, the brothers are agents of the government, dealing with evil alchemists and on a constant search for the Philosopher's Stone, the fabled alchemical treasure that is their only hope of being returned to normal.

The ongoing quest to seek the legendary Philosopher's Stone moves into two venues: the depths of the homunculus Gluttony, and a political power struggle, as the military faces irreparable damage when Colonel Mustang confronts Fuhrer President King Bradley with his suspicion that Bradley is a homunculus.

"As the battle for Central City rages on, Alphonse faces off against Pride and Kimblee with the aid of a Philosopher's Stone. Can he come up with a plan to take down these two dangerous foes? Meanwhile, Ed and his friends run into Envy below the city. When Roy Mustang learns the truth about Hughes's murder, will he be consumed by hatred and do the unthinkable?" -- from publisher's web site.

As Greed and King Bradley continue their battle, the mysterious homunculus "father" makes his move under Central City. In order to achieve his objectives, he will need to force Mustang to make an unthinkable choice. Meanwhile, Alphonse has the chance to regain his own body, but the sacrifice to do so may be too much.

"In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical 'auto-mail' limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone. Betrayal and double-crossing are the order of the day. Greed, Pride and Envy prove to be formidable enemies, but one homunculus...

Kazuki Muto was transformed into a Buso Renkin by Tokiko after he was killed by a homunculus, a flesh-eating monster. Now, Kazuki and Tokiko are racing against time to find the creator of the homunculi before the one that is lodged at Tokiko's waist reaches her brain and transforms her into a homunculus. Unknown to them, the person they seek is a student at Kazuki's school.